Cosequin Optimized Formula with MSM contains higher levels of active ingredients, now with glucosamine hydrochloride at 14,400mg and with 2,400mg of chondroitin sulfate (per 2 scoops), plus has the further addition of high purity MSM, methylsulfonylmethane. MSM is an organic source of sulfur, a compound used by cartilage. Contains 10,000mg MSM per 2 scoops.